G protein coupled receptors (GPCRs) are a large family of membrane proteins that play a crucial role in cell signaling. GPCRs are activated by a wide range of ligands, including hormones, neurotransmitters, and other signaling molecules. Upon ligand binding, GPCRs undergo a conformational change that activates downstream signaling pathways, leading to various cellular responses. Research in the area of GPCR activation focuses on understanding the molecular mechanisms by which ligand binding leads to receptor activation, as well as the downstream signaling pathways that are activated in response to GPCR activation. This research is important for developing new drugs that target GPCRs and regulate their signaling pathways, which can have implications for a wide range of diseases and conditions. Additionally, studying GPCR activation can provide insights into the basic mechanisms of cell signaling and communication.